Discovery Blog

The new CellMaker Plus bioreactor system from Cellexus Limited promises to revolutionize the way that cells are cultured for protein expression and other applications. The Company designed the new system specifically for efficient growth of the widest range of cell types including bacteria, yeast, algae, bacteriophage as well as the more challenging mammalian and insect cells. This single-use bioreactor system, which will be  available with both 8L and 50L capacities to provide flexibility in scale, incorporates a wealth of new technologies to improve processes and speed up set-up times. It includes a patented air dispersion system to effectively aerate and mix the cell culture and features a modular control system which is flexible and adaptable and can be configured to satisfy the specific needs of an application.

The CellMaker PLUS consists of four modules, the enclosure (please see below), a controller, a supply hub and an oxygenator. The enclosure holds a CellexusBag which is a unique, single-use, disposable cell culture bag that allows for fast set-up times and the elimination of lengthy cleaning protocols. Whereas other disposable systems require shakers, rockers, rollers or large environmental chambers, the CellMaker PLUS employs proprietary airlift technology to mix, aerate and maintain cell suspension.

This system is simple, scalable and inexpensive to use. The CellMaker PLUS controller allows for precise management of temperature (from 15 to 45⁰C), controls the flow and mix of sparge gas and enables monitoring and control of pH and dissolved oxygen (DO). Accurate control of these parameters enables optimization of culture growth and improved expression levels of soluble protein.